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Proposal Requirement 2 Example: Chelation Therapy for Alzheimer's

Writer: Natasha Matta

Instagram: @natashakmatta

Email: matta.natashak@gmail.com


Abstract

Alzheimer’s disease is the sixth leading cause of death in the United States. It is most likely caused by oxidative stress and the buildup of plaques, clusters of beta-amyloid protein that accumulate in the spaces between neurons. Current treatments for Alzheimer’s disease include cholinesterase inhibitors, which prevent breakdown of acetylcholine, a neurotransmitter important for memory and processing, like Razadyne® (galantamine), Exelon® (rivastigmine), and Aricept® (donepezil) and N-methyl D-aspartate (NMDA) antagonist Namenda® (memantine) that regulates glutamate, which can become toxic to the brain in large amounts. Chelation therapy removes metals from the bloodstream and is used to treat heavy metal poisoning, and the catalase enzyme naturally combats oxidative stress by decomposing hydrogen peroxide into oxygen and water. New research points to chelating metal ions in the bloodstream like zinc, copper, and iron that lead to the aggregation of beta-amyloid proteins and interfere with catalase enzyme activity to more effectively treat Alzheimer’s.


Analysis

The abstract begins by briefly establishing the importance of the issue (Alzheimer’s disease is the sixth leading cause of death in the United States), immediately drawing the reader in. It discusses current treatments and their insufficiencies before proposing a more effective potential treatment option (chelation therapy). Scientific terminology like beta-amyloid plaques, oxidative stress, catalase enzyme activity, and chelation therapy were all defined to make the abstract easier to understand for readers. The writer employs correct spelling, grammar, and formatting, sticks to the 150 word limit, does not include figures or images in the abstract, and uses reputable sources from medical centers and scientific journals.


References

Alzheimer’s Disease Fact Sheet, National Institute on Aging, https://www.nia.nih.gov/health/alzheimers-disease-fact-sheet

How Is Alzheimer’s Disease Treated?, National Institute on Aging, https://www.nia.nih.gov/health/how-alzheimers-disease-treated#:~:text=Medications%20called%20cholinesterase%20inhibitors%20are,and%20Aricept%C2%AE%20(donepezil).

Chelation Therapy, University of Michigan: Michigan Medicine, https://www.uofmhealth.org/health-library/ty3205spec

Alzheimer’s disease, Mayo Clinic, https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/symptoms-causes/syc-20350447

Role of oxidative stress in Alzhimer’s disease, Biomedical Reports, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840676/#:~:text=Oxidative%20stress%2C%20a%20process%20increased,the%20antioxidant%20system%20(1).

Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases, Oxidative Medicine and Cellular Longevity, https://www.hindawi.com/journals/omcl/2019/9613090/

Unraveling Alzheimer’s Disease, Boston University, http://www.bu.edu/brink/series/alzheimers-research/

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